How Octreotide Works
A 2014 study in the PKD animal model shows Tolvaptan + octreotide to have a synergistic effect on cyst formation, better than either one alone.
Researchers scanned the
surface of liver cysts with an electron microscope. Liver cyst cell surface contained:
hormone receptors, insulin growth hormone receptors and growth hormone receptors. According to the electron microscope article:
Estrogens act not only directly but also by promoting the synthesis and release of growth factors from the cyst epithelium. Our study furnishes the scientific background for the clinical observations showing how the formation and progression of hepatic cysts is highly sensitive to changes in the estrogen status in the body.
Octreotide inhibits all of the liver cell surface receptors: growth hormone receptor, it inhibits insulin growth hormone receptors and it inhibits estrogen receptors.
How does Sandostatin LAR work?
It has little polymers within the injection so the medication cannot be shaken or mixed upside down. This can cause the polymers to break. To read more try Novartis website.
