Osteoporosis
Osteoporosis can come about from chronic kidney disease, aging, steroids, sedentary life, eating an acidic diet (mostly animal proteins), lack of vitamin D, lack of calcium, thyroid disease, alcohol, difficulties with the parathyroid, celiac disease quadruples the risk, and taking certain medications.
According to Lisa Guay-Woodford M.D. speaking on PKD, osteoporosis is a very big problem in women who are postmenopausal, and estrogen therapy has some benefit. It has an added benefit in cardiovascular. There is a trade off. The physician has to adjust the risk and benefits for treatment. Some of the osteoprosis medications have questionable side effects especially for those with diminished kidney functioning. The FDA is in agreement that some type of caution should be placed on the long term use of bisphosphonates due to spontaneous femur fractures occurring. They could not agree on the length of time.