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Octreotide

Octreotide Sandostatin LAR

A somatostatin analogue, octreotide, is the first medication in clinical trials for polycystic liver disease. This long acting form of somatostatin is manufactured by Novartis. It has been used successfully to treat acromegaly, carcinoid, and other rare endocrine tumors.

Octreotide Clinical Trial

The first trial was undertaken in Bergamo, Italy at the Mario Negri Center. The Mario Negri Center completed a small Somatostatin trial with 12 patients that determined Octreotide LAR to be safe and that it reduced polycystic kidney size. One participant withdrew from non symptomatic gall stones. Another withdrew from asthenia (weakness, lack of energy and loss of strength) There is a current ongoing phase II octreotide clinical trial that is yet to be completed at the Mayo Clinic in Rochester Minnesota USA with 42 participants. The trial is determining if long acting injectable octreotide (given once every 28 days) is useful in reducing severe polycystic liver disease. Phase II will complete in about a year. The Mayo is considering another trial for individuals who have never taken octreotide. A trial in the Netherlands using an analogue of sandostatin (octreotide, lanreotide) is finished. A third trial in Italy is underway to determine if octreotide reduces liver cysts. Another is in Belguim, Netherlands and more. Search for all current octreotide clinical trials here.

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We are  sharing our experiences with PLD Diet, an adjunct diet to consider  trying to complement a physician's prescribed medical therapy. Think  about testing this only with your doctor's prior knowledge, who can  adjust it, according to your own uniqueness by adding to your current  treatment.

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