PKD DIET

Sirolimus Rapamycin

Avoid Wait for PKD Trials to Complete

Wait for PKD trials to complete. Avoid these mTor drugs for now.

Transplant

If individuals are already taking sirolimus for a transplanted organ, the Mayo is following ADPKD patients with PLD to keep a record of how their PLD liver size is doing. A PLD liver is reported to shrink while individuals are on sirolimus. Sirolimus also decreases metalloestrogens.

FDA ALERT

The FDA has issued a warning about sirolimus. The FDA is notifying healthcare professionals of clinical trial data that suggest increased mortality in stable liver transplant patients after conversion from a calcineurin inhibitor (CNI)-based immunosuppressive regimen to sirolimus (Rapamune). The trial was conducted by sirolimus manufacturer, Wyeth. As early as 2002, Wyeth issued a warning about not using sirolimus with liver transplantees. Below is an excerpt from that article:

Everolimus (Afinitor)

Everolimus (afinitor) is also an mTor inhibitor and very similar to sirolimus. There was a German trial in humans for the treatment of PKD. It can also cause a shrinkage of a PLD liver. These are immunosuppressive drugs. FDA issued a warning following a trial that switching to sirolimus caused an increase in death rates. Afinitor, has many many side effects.

↓ PLD liver size
↓ PKD kidney growth
Slowed down kidney volume
↓ metalloestrogens
↑ death rates

We are  sharing our experiences with PKD/PLD Diet, an adjunct diet envisioning it complementing a physician's prescribed medical therapy. Consider testing this with your doctor's prior knowledge, who can  adjust it according to your own uniqueness by adding it to your current  treatment.

Medical Disclaimer