Turkey: A completed clinical trial in Turkey with 224 patients concluded that overnight hemodialysis for 8 hours with a blood flow rate 200-250 ml/min, was found to be superior to day time dialysis for 4 hours with a blood flow rate 300-400 ml/min. Both were done (3) three times a week. Overnight hemodialysis group saw an 80% reduction in overall death rates; had better blood pressure control, leading to a two-thirds reduction in blood pressure medications. They were also at lower risk of blood pressure drops during dialysis, a common problem with conventional hemodialysis. Levels of the mineral phosphate decreased toward normal, despite a 72% percent reduction in medications used to lessen phosphate absorption. Most patients in the overnight hemodialysis group mentioned an increase in appetite. They gained weight, and their serum protein (albumin) levels increased. Many patients were able to return to work, reporting improved job performance and better mental (cognitive) functioning.

Italy: The Italian Society of Nephrology found that long nocturnal hemodialysis every other night appears to be more appealing to patients than 5 to 7 dialysis sessions a week.

Netherlands: From the Netherlands a trial found that patients after 6 months of in-center nocturnal hemodialysis had significant improvements in subjective and objective sleep parameters and partially restored nocturnal melatonin rhythm.

Canada: Effect nocturnal dialysis vs conventional dialysis on left ventricular mass & quality of life: a randomized controlled trial Canada
This preliminary study revealed that, compared with conventional hemodialysis (3 times weekly), frequent nocturnal hemodialysis improved left ventricular mass, reduced the need for blood pressure medications, improved some measures of mineral metabolism, and improved selected measures of quality of life.

USA Dr. Amy Williams, at the Mayo clinic in Rochester Minnesota, has been using nocturnal hemodialysis 5- 6 times a week. Children undergoing overnight dialysis could awaken enthused and rested, ready for a day in school, similar to normal children. Adults experienced a greatly improved quality of life. Individuals undergoing dialysis by these methods felt so good, looked healthier than the staff, and one of the side effects was an improvement in couples' amorous enthusiasm. With three times a week dialysis there was a significant improvement, 4 times a week a bit more, and by 5 + times a week it was the equivalent of when they were in their twenties.