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Joint Pain

Kidney Pain Liver Pain Chronic Pain Aspirin Back Pain Headache Aneurysm Joint Pain Leg Cramps Tooth Pain Surgery Pain Chest Pain                                                                                    JOINT PAIN - GREAT TOE PAIN Individuals with PKD have elevations of body acids, especially urinary uric acid. PLD 'rs often have elevated uric acid levels from the liver's inability to metabolize body acids. This sometimes manifests as gouty arthritis, or pain in the great toe. The pain is from uric acid crystals trapped within the joint. Sometimes I get great toe pain. I have found that by avoiding raw spinach (high in oxalates) and the nightshade plants (tomatoes, potatoes, eggplant, peppers, tobacco and belladonna) these joints do not ache. If the toe does act up, I take foods which help to lower uric acid, i.e. ten cherries a day, nettles, artichokes, a shot of wheat grass juice, or I chew on a few sprigs of parsley. Nettle juice lowers uric acid, is a great alkalizer, however it is also high in potassium. A few drops of non alcoholic nettle extract in a cup of warm water seem to help relieve great toe aches. Cherries, ten a day, helps with arthritis pain by lowering uric acid. A rheumatologist told me, he investigated all the different foods that seemed to help arthritis and one that was really helpful were cherries. Attempting to maintain a constant relative alkalinity helps to diminish body pains from cystic organ disease. This can be accomplished through diet and lifestyle and by supplementing occasionally with potent alkalizers. JOINT PAIN - ARTHRITIS I drink the juice of two freshly squeezed lemons each morning and I have the juice from about a two inch wedge of a cabbage juiced with 5 almonds. If this does not relieve the pain, then I start with 10 cherries (I must confess I have sometimes eaten maraschino cherries if I cannot get frozen or fresh) and this did make the joint pain go away but by morning, I had a migraine headache from the sugars and dye in the maraschino cherries. If I am traveling, I might stop in a jamba juice bar and get a one ounce shot of wheat grass followed by a bite into an orange slice.     Glucosamine-Chondroitin Scores Big in Pain Test   ACR: No Clear Benefit for Painful Knees in Big Glucosamine-Chondroitin Study   Glucosamine, Chondroitin Sulfate, and the Two in Combination for Painful Knee Osteoarthritis - abstract   Glucosamine, Chondroitin Sulfate, and the Two in Combination for Painful Knee Osteoarthritis - full article GAIT Study Results (Glucosamine/Chondroitin Arthritis Intervention Trial-GAIT) Volume 354:795-808 February 23, 2006 Number 8 Background Glucosamine and chondroitin sulfate are used to treat osteoarthritis. The multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) evaluated their efficacy and safety as a treatment for knee pain from osteoarthritis. Methods 1583 patients with symptomatic knee osteoarthritis to receive 1500 mg of glucosamine daily, 1200 mg of chondroitin sulfate daily, both glucosamine and chondroitin sulfate, 200 mg of celecoxib daily, or placebo for 24 weeks. Conclusions Glucosamine and chondroitin sulfate alone or in combination did not reduce pain effectively in the overall group of patients with osteoarthritis of the knee. Exploratory analyses suggest that the combination of glucosamine and chondroitin sulfate may be effective in the subgroup of patients with moderate-to-severe knee pain. Our finding that the combination of glucosamine and chondroitin sulfate may have some efficacy in patients with moderate-to-severe symptoms is interesting but must be confirmed by another trial.   Efficacy of Glucosamine and Chondroitin Sulfate May Depend on Level of Osteoarthritis Pain - NIH news   What Effects Do NSAIDs and Dietary Supplements Have on Cardiovascular Risk? Glucosamine and chondroitin sulfate have been proposed as a way to forestall arthritis or arthritis pain because they are precursors of the proteoglycans in cartilage that tend to erode in osteoarthritis. While there is a lot of anecdotal evidence and popular interest in these substances, the latest clinical trial of their use for this purpose has been disappointing. The Glucosamine/chondroitin Arthritis Intervention Trial (GAIT), a randomized, placebo- and celecoxib-controlled trial of glucosamine, chondroitin sulfate, or the two in combination showed no objective evidence of benefit on osteoarthritic knee pain. Folic acid is probably important in keeping levels of homocysteine down. Elevated homocysteine is an independent risk factor for atherothrombosis. Those individuals who have hyperhomocysteinemia on a genetic basis tend to have thrombotic disease at a young age. However, in the general population, the hazards of homocysteine may be considered fairly minor. For example, higher values of C-reactive protein confer about a two-fold increase in risk when corrected for everything else. It appears that in a large population, however, homocysteine gives a relative risk of only approximately   Chondroitin sulfate Mayo Chondroitin was first extracted and purified in the 1960s. It is currently manufactured from natural sources (shark/beef cartilage or bovine trachea) or by synthetic means. Chondroitin is a simple molecule that occurs naturally in the body. It is a major component of cartilage -- the tough, connective tissue that cushions the joints. Chondroitin helps to keep cartilage resilient by absorbing fluid (particularly water) into the connective tissue. It is also believed to block enzymes that break down cartilage and it provides the building blocks needed for cartilage to repair itself.   Glucosamine Mayo The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. CONCLUSION: This study demonstrates that oral glucosamine supplementation does not result in clinically significant alterations in glucose metabolism in patients with type 2 diabetes mellitus. Why is Glucosamine and Chondroitin best avoided with PKD? It is made from shellfish and shark cartilage, these are high in copper and high in oxalates, which are detrimental to individuals with PKD. There is a completed study called the GAIT clinical trial. This was a multi-center trial of 1500 individuals Glucosamine/chondroitin Arthritis Intervention Trial (GAIT), a 24-week. Conclusions Glucosamine and chondroitin sulfate alone or in combination did not reduce pain effectively in the overall group of patients with osteoarthritis of the knee. Analyses suggest that the combination of glucosamine and chondroitin sulfate may be effective in the subgroup of patients with moderate-to-severe knee pain must be confirmed by another trial. Here is another link. The good news is that a recent clinical trial of Glucosamine supplementation showed that it does not affect blood sugar in individuals with type 2 diabetes mellitus The American College of Radiologists concluded that there was no pain benefit except possibly in severe cases of knee osteoarthritis. The pain was rated against a known pain scale. This differs from a small European study done by the manufacturers of Chondroitin.