The above are myocystes, heart cells, adversely affected by caffeine.
Many of us with PKD or PLD have observed that by eliminating caffeine we have a lessening of pain from our surrounding our cystic kidneys and cystic liver. Caffeine stimulates cyclic AMP. Cyclic AMP increases cyst growth and expansion. Tolvaptan an experimental drug to reduce kidney cyst growth. One mechanism of tolvaptan's action is to blocks the binding at receptor sites of cyclic AMP. Even small amounts of caffeine contained in de-caf chocolate or de-caf organic green tea have increased pain within our cystic kidneys, as well as increased abdominal girth from liver cyst expansion and growth.
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on the  green arrow or the blue links to read several caffeine articles.
Looking at coffee oils & gallstones researchers found a source of gallstones to be tamarind.
Cafestol Coffee oils raise cholesterol esp triglycerides LDL HDL. Reproducible 2005
Coffee bean extracts kahweol elevate liver enzymes in healthy individuals. 2004
Coffee - Association Parkinson's and coffee
Caffeine - Abstract - Chronic consumption exacerbates hypertension in PKD rats
Caffeine - Full article - Chronic consumption exacerbates hypertension in PKD model
Coffee - Caffeine increases kidney stones formation. (Massey 2004)
Caffeine's effect on PKD stimulates cyst growth by stimulating C-amp.
Coffee PKD stimulates cyst growth in PKD kidneys by stimulating C-amp.
Coffee stimulates bad cholesterol NY times article
BP
Caffeine- Habitual caffeine intake and risk of hypertension in women
Coffee caffeine alters signaling LVH to the heart ADPKD cardiomyocytes altered signaling.
Coffee caffeine alters smooth muscle calcium stores vascular phenotype in PKD Torres
Caffeine increases excretion of minerals for 3 hours contributes to lessening bone density.
Decaffeinated' Coffee May Be Anything But
Caffeine and kidney stones
Caffeine's effect on PKD cyst growth by stimulating Cyclic amp
The effects of caffeine and coffee on health, a few papers from Teeccino an herbal coffee.
Quitting caffeine painlessly by Teeccino an herbal coffee.
Caffeine raises PKD blood pressure. Elevations in blood pressure contributes to the many vascular and cardiac manifestations of PKD - such as left ventricular hypertrophy LVH or an increase in the mass of the left heart ventricle. Many PKD'rs are maintaining blood pressure near 100/70 - 110/70 - 120/80. This lower consistent blood pressure is thought to be key in delaying dialysis by 15 years or more. Whereas uncontrolled PKD blood pressure correlates with much more rapid decline in kidney failure.
The number one cause of death from Polycystic Kidneys is left ventricular hypertrophy— LVH or heart disease. Surprisingly it is not kidney failure. Cystic kidneys do fail but generally this is not what causes death, it is the heart and the blood vessels. This is why there is such an interest in cardiomyocytes, caffeine and polycystin 2. There is an ongoing 5 year HALT PKD blood pressure trial underway. Check out the HALT website or send an Email if you are willing to volunteer. More on research and other clinical trials is available here. Caffeinated beverages should be discouraged because caffeine inhibits phosphodiesterase; enhances cAMP accumulation; and potentiates the effects of vasopressin on chloride secretion, cell proliferation, and cyst growth, at least in vitro (27).
27. Belibi FA, Wallace DP, Yamaguchi T, Christensen M, Reif
G, Grantham JJ: The effect of caffeine on renal epithelial
cells from patients with autosomal dominant polycystic
kidney disease. J Am Soc Nephrol 13: 2723–2729, 2002
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