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COLCHICINE
Meadow Saffron or Autumnal Saffron

    Colchicine treatment in autosomal dominant polycystic kidney disease

"Colchicine, originally extracted from Colchicum autunale, is an anti-inflammatory drug that has been in continuous use for more than 3000 years. It has been used successfully to prevent attacks of familial Mediterranean fever and amyloidosis, to treat gout and pseudogout attacks for a few decades. Colchicine principally is a microtubule inhibitor, thus prevents cell migration, division, and polarization. It also has anti-apoptotic, anti-proliferative and anti-inflammatory effects and down-regulates (TNF-alpha) receptors. As can easily be seen, many of the effects of colchicine have pathophysiologic counterparts in ADPKD. Thus, we hypothesized that colchicine would be beneficial to prevent or at least delay cyst formation in ADPKD patients. Indirect evidence also support our hypothesis, in which taxol and paclitaxel, other two microtubule inhibitors, were shown to delay cyst formation in experimental models of ADPKD. To our opinion, despite its narrow therapeutic index, widespread experience makes colchicine a suitable candidate for prolonged clinical use, should experimental studies show any benefit in ADPKD.
"  – From Selcuk University, Meram School of Medicine, Nephrology Department, Meram, Konya, Turkey.

Meadow saffron or autumn crocus, perennial garden ornamental ( Colchicum autumnale ) of the family Liliaceae (lily family). Native to Europe and N Africa, it has escaped from gardens to meadows and fields in some parts of the United States. Its poisonous corms and seeds were the source of the drug colchicine . The purplish flowers, which bloom in the fall when the leaves are gone, resemble those of true crocus and true saffron (of the iris family) but these have six stamens instead of three. Other species of Colchicum are also popular garden plants. Meadow saffron is classified in the division Magnoliophyta , class Liliopsida, order Liliales, family Liliaceae.

          

 

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last updated: Saturday, August 13, 2011 6:03 AM