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--select a POTASSIUM CITRATE webpage-- K Cit K Cit notes K Cit PKD-Tanner K Cit more K Cit articles K Cit potassium K Cit begin K Cit test pH Monitor pH Alkalizer Potassium Symptoms ↑ ↓

Citrate Therapy for Polycystic Kidney Disease in Rats

Nephron Physiol. 2003 Jan;93(1):P14-20.
Tanner GA, Tanner JA.

Potassium Citrate/Citric Acid Intake Improves Renal Functioning in PKD Models

Progression of autosomal-dominant polycystic kidney disease (ADPKD) in the heterozygous male Han:SPRD rat is dramatically slowed by ingestion of potassium or sodium citrate.

Dietary Treatment of PKD in Rats

These Alkaline PKD researchers have given us conclusive scientific evidence showing that in the PKD model, those fed an alkalizer [potassium citrate] not only lived almost twice as long lives, but the PKD model on the alkaline diet, did not go on to kidney failure and their cystic kidneys never enlarged to typically huge PKD polycystic kidneys. Whereas their counterparts NOT fed potassium citrate died at 10 months, developed kidney failure; and did develop huge polycystic kidneys. This lecture was given to a standing room only backed up all the way down the hallway with eager PKD'rs at a PKD conference. This was the first time we had ever seen such a turn out for such an outstanding standing room only PKD lecture.

We are grateful to have available to us, the detailed potassium citrate clinical research undertaken by these dedicated scientists - Judy Tanner and George Tanner. It is through their work that we with PKD have come to learn the benefits of remaining alkaline. The Tanners performed some very precise detailed experiments that led to the discovery that potassium alone helped PKD and citrate alone helped PKD, but by far and away the most benefit was obtained from alkalinity.

Before beginning citrate salts check urinary citrate levels. This should be low as is to be expected with PKD. Get baseline electrolytes with base excess, and a urinary pH. Start the potassium citrate, sodium citrate, calcium citrate or magnesium citrate. Every other day initially get serum potassium x 3 days. Then get checked once a week, then once a month for two months, then once a quarter for two quarters, then once every 6 months, then once a year. Familiarize yourself with the symptoms of high and low serum potassium.

Citrate is utilized by the kidneys as energy. Sodium citrate and potassium citrate were equally effective alkalizers. Calcium citrate was less so. In the normal progression of PKD towards end stage renal disease, potassium rises. Many doctors oftentimes prescribe a favorite old standby, sodium bicarb, as an inexpensive alkalizer. However due to the inherent nature of PKD, this will lead to an increase in kidney stone formation, especially for PKD'rs. We already have a 20% increased risk of developing kidney stones. Taking sodium bicarbonate multiplies this risk. Ask your nephrologist if sodium citrate might prove beneficial for you. Not only is potassium citrate or alkalinity beneficial for PKD, there are some clinical trials that show it also helps lower blood pressure and improve bone density and diminish recurrent kidney stone formation.

Empirical Knowledge is Knowledge Grasped from Within

I liken Potassium Citrate PKD Researchers, Judy and George Tanner to a young Galileo trying to refute a thousand year old theory first established by a Greek named Aristotle. We with cystic organs know that something is true, because we have experienced it. It is true at least for ourself alone within a private set of circumstances within our own particular body. We are akin to the ancient Romans, the Italians, wishing to conduct a practical clinical trial to see if an experiment might prove the likelihood of potassium or sodium citrate working to diminish symptoms in humans with PKD. If it does not work, then we wish to know why it will not work.

Perhaps a few nephrologists are having leanings toward prescribing potassium citrate for PKD'rs much like the famous leaning tower. Galileo is said to have dropped a bag of feathers and a ball simultaneously from the top of the leaning tower of Pisa. This was the beginning of the science of free fall acceleration. Galileo Galilei was condemned for his theories by his church for promoting a Copernican cosmology. Aristotle's theory proclaimed that the heavier object would fall and hit the ground at a much faster rate. In 1992 scientists at the University of Pisa confirmed the correctness of Galileo's theory. Even today Galileo is still capable of provoking controversy. Read about Pope Benedict XVI canceling his planned visit to a prestigious Italian university after a protest by academics and students attacked his views on Galileo. Galileo was born in 1564, the same year as Shakespeare and the year in which Michelangelo and Calvin died. Benedetti Giambattista had already published a comparable experiment in 1553. Another similar test had been completed by the Flemish engineer Simon Stevin in 1586.

Fly Me to the Moon

Commander David R Scott (2 August 1971, lunar surface).
"Well, in my left hand I have a feather; in my right hand, a hammer. And I guess one of the reasons we got here today was because of a gentleman named Galileo, a long time ago, who made a rather significant discovery about falling objects in gravity fields. And we thought: 'Where would be a better place to confirm his findings than on the Moon?"

[Camera zooms in on Scott's hands. One is holding a feather, the other a hammer. The camera pulls back to show the Falcon ­ the Apollo 15 landing craft ­ and the lunar horizon.] "We thought we'd try it here for you. The feather happens to be, appropriately, a falcon feather for our Falcon. And I'll drop the two of them here and, hopefully, they'll hit the ground at the same time." [Scott releases hammer and feather. They hit the ground at about the same time.]

"How about that! Mr. Galileo was correct in his findings."

The truth that objects of different masses fall at the same rate inside a vacuum, is associated with a single person (Galileo) and a single place, the Leaning Tower of Pisa. The culprit who has told the world about this is said to be Vincenzio Viviani, Galileo's secretary who wrote in the final years of Galileo's life.

Potassium Citrate has been used by NASA to prevent bone loss experienced during space travel.

- select a POTASSIUM CITRATE article - K+ CIT PKD improves GFR in PKD 1998 K+ CIT Abstract improves PKD 1998 K+ CIT therapy for PKD 2000 K+ CIT Dietary Treatment PKD 2003 K+ CIT does not harm PCY mouse 2005 K+ CIT bio Tanner Kcit 2012 supplementation sustained improvement in calcium balance Kcit 2012 a potent alkalizer, helps kidney failure in dogs Kcit 2012 renal insufficiency in a patient with enteric hyperoxaluria Improved Kcit 2012 Vegetarian diets and blood pressure Kcit 2011 Splenda® improves tolerance of oral potassium citrate supplementation double-blind trial Kcit 2007 Acid-alkaline balance: role in chronic disease and detoxification Kcit 2010 Nutrient based estimation of acid-base balance in vegetarians and non-vegetarians POTASSIUM hi and low symptoms ALKALINITY potassium salts + effects ALKALINITY sprint performance ALKALINITY candida yeast ALKALINITY Alkaline diet weight loss ALKALINITY vegan dogs live longer ALKALINITY plant juices & Alzheimer's ALKALINITY nanobacteria ALKALINITY PKD nanobacteria. ALKALINITY effective renal-protection diet ALKALINITY Saving failing kidneys ALKALINITY LDL cholesteroL triglycerides ALKALINITY Raw vegan Leaner healthier ALKALINITY Vegan diet health benefits UV ALKALINITY Raw vegan vitamin D ALKALINITY Vegan bests ADA diet ALKALINITY Improves Bone Health BP associated with 24 hr citrate BP short term Kcit therapy BP Hypertension BP Kcit associated with 24 hr citrate BP Kcit short term Kcit therapy BP Kcit Hypertension BLOOD PRESSURE Cold Weather ↑ BP BLOOD PRESSURE Less Sleep ↑ BP BP Deep Sleep Dreamers Enjoy Normal BP BP Salt restriction, a missed opportunity? help ↓ BP BP salt restriction vs meds ESRD hemodialysis ↓ LVH and ↓ BP BLOOD PRESSURE grape juice help ↓ BP BP avoiding these 15 foods help ↓ BP BLOOD PRESSURE avoiding allergic foods will help ↓ BP BLOOD PRESSURE Citrate help ↓ BP BLOOD PRESSURE urinary citrate BLOOD PRESSURE Potassium Citrate BLOOD PRESSURE Folate Intake help ↓ BP BLOOD PRESSURE salt and Sugary Drinks May ↑ BP BLOOD PRESSURE Caffeine ↑ PKD model BP BLOOD PRESSURE Caffeine ↑ BP BP Vitamin D May Explain Racial BP Disparities in blood pressure BLOOD PRESSURE optimal care ADPKD BLOOD PRESSURE renin-angiotensin BLOOD PRESSURE Controlling PKD BP Listen to Lecture BLOOD PRESSURE Renin Angiotensin BLOOD PRESSURE facts about PKD Hypertension most common symptom BLOOD PRESSURE Rigorous BP control ADPKD BLOOD PRESSURE Young PKD Adults BLOOD PRESSURE early diagnosis PKD BLOOD PRESSURE PKD importance of family history BLOOD PRESSURE 1 in 5 Young Adults May Have ↑ BP BLOOD PRESSURE heart disease death BONES Kcit therapy BONES Kcit partial neutralization with Kcit of West Diet BONES turnover postmenopausal women COLCHICINE vascular expression Polycystin-2 COLCHICINE treatment ADPKD DENTS potassium citrate helps ALKALINE DIET Clinical Trials DIET DIET vegetarian DIET Melon juice DIET 5 Servings a Day ↓ CKD DIET Fruits and Vegetables or Oral NaHCO3 Preserve GFR DIET Protein Restriction in Treatment CKD DIET Acid-Alkaline Role in CKD DIET Acid Retention DE Wesson MD DIET Key to Halting CKD might in ↑ Produce DIET Red Meat Consumption & Mortality DIET Alternative Healthy Eating Index & Mortality DIET Dog Health Survey DIET Dirty Dozen Food Guide DIET Dietary Citrate ↓ PKD in Rats DIET Veggie diet best for kidney disease DIET Melon Juice Non-citrus juices DIET keeping kidney volume low, keeps kidney functioning good DIET eating red meat may mean quicker death DIET salt intake blunts ACE inhibitors accelerates kidney disease DIET-induced metabolic acidosis DIET key to halting CKD in market DIET red meat consumption mortality DIET 18yr follow up Healthy Eating DIET Fatty Liver on Rise in Teens DIET progressive ↓ GFR ↑ by alkaline diet DIET PlanEat, a short movie trailer DIET Heart attack proof diet DIET ↑ fruits veg helps kidney injury DIET acid ↓ GFR ↑ plasma aldosterone DIET endothelins and kidney acidification DIET acid retention in humans DIET High and Low Potassium Symptoms DIET CITRATE melon juice and citrus juices for alkalinity DIET CITRATE Lemonade Based Dietary Manipulation DIET lo-cal aides longevity DIET vegetarian ↓ BP NANOBACTERIA NANOBACTERIA controversial pathogens in nephrolithiasis and PKD NANOBACTERIA Antimicrobial Drugs NANOBACTERIA isolation, propagation, and analysis of nano particles NANOBACTERIA Biomineralization Induced by Stress NANOBACTERIA Endotoxins in PKD NANOBACTERIA controversial pathogens in nephrolithiasis PKD NANOBACTERIA may be linked to calcification in placenta 2012 NANOBACTERIA protein-mineral complexes 2011 NANOBACTERIA role of calcifying nanoparticles in biology and medicine 2012 NANOBACTERIA PKD Unrecognized Emerging Infectious Disease? NANOBACTERIA alkaline phosphatase human- derived nanoparticles in vitro NANOBACTERIUM wikipedia NANOBACTERIUM The Truth NANOBACTERIUM The Rise and Fall NETTLE cholesterol NETTLE reduces creatinine SODIUM BICARB increases stones SODIUM BICARB increases kidney stones SODIUM BICARB Aggravates PKD model SODIUM BICARB Forms Stones in PKD SODIUM BICARB slow CKD progression SODIUM BICARBONATE forms kidney stones in PKD SODIUM BICARBONATE Aggravation PKD in Han:SPRD Rats PKD SODIUM BICARBONATE Clinical study mineral waters containing bicarbonate SODIUM BICARBONATE Baking soda may slow progression of CKD SODIUM BICARBONATE Urinary alkalization Rx for uric acid stones SODIUM BICARBONATE potassium depletion increases risk for urinary stone STONES Kcit lithotripsy STONES Alkaline Citrate useful lithotripsy STONES Kcit lithotripsy STONES treatment with Kcit STONES Magnesium therapy for stones URIC ACID ADPKD URATE in ADPKD URIC ACID gout in ADPKD URIC ACID hyperurecemia in ADPKD UROCIT UROCIT polycitra K UROCIT K YEAST candida helped by Kcit

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We are  sharing our experiences with PKD/PLD Diet, an adjunct diet envisioning it complementing a physician's prescribed medical therapy. Consider testing this with your doctor's prior knowledge, who can  adjust it according to your own uniqueness by adding it to your current  treatment.

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