DCA Dichloroacetate
DCA Dichloroacetate in tap water
Dichloroacetate a common contaminant in chlorinated city water can accelerate cyst formation in the ARPKD model. Addition of bleach to city water is harmful to cystic organs. This is a residual acetate formed with chlorination. Careful of chlorine in city water. One can leave tap water out for 24 hours to dissipate the chlorine. Others have tried the use of a water filter that eliminates chlorine and others have tried aeration.When skin cells are warmed and dilated like when in a hot shower, there is increased chlorine absorption as well as increased absorption of the contaminant dichloroacetate. Some have used shower filters to deter this from happening.
Scientists discovered that in the ARPKD model dichloroacetate accelerates cyst development. Dichloroacetate a contaminant from chlorination in some city tap water, may account for the differing results from drinking copious amounts of water in ADPKD clinical water trials. Japan has a high level of DCA in their city water.
2014
The advantages of drinking water early in the treatment of ADPKD is explained in an article by Dr. Grantham.↑ water intake PKD
"Although evidence is lacking to support increased water intake in the general population, available evidence indicates that individuals who are at risk for nephrolithiasis as well as those with CKD and PKD may benefit from 3-4 Liters of urine output each day, a level of excretion that is likely to be safe."Low Osmolar Diet and Adjusted Water Intake for Vasopressin Suppression in ADPKD
This is a clinical water trial at Tufts University with Dr. Perrone. Its title is Diet as a Potential Treatment for Autosomal Dominant Polycystic Kidney Disease.Increasing water intake for some can improve PKD kidney health
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