Cascara sagrada
Avoid Cascara sagrada
(Rhamnus purshiana)
California buckthorn
emodin
Cascara has estrogenic effects. It should be avoided due to its harmful effects for a PLD liver. It can cause cholestatic hepatitis. Anthraquinone-containing herbs like cascara sagrada should not be used by people with diverticular disease as cascara can aggravate diverticula symptoms. Avoid cascara as it is detrimental to PKD/PLD. Its chronic use chronic use disturbs the electrolyte balance, especially potassium deficiency, causing a circulus vitiosus and a dependency on purgative dietary supplements.
Study of Herbal Supplements
Cascara is genotoxic at every dose level given.